N-甲基-D-天门冬胺酸受体(英语:N-methyl-D-aspartate receptor,简称NMDA受体或NMDAR)为麸胺酸盐受体,是一个主要的分子装置,控制突触的可塑性与记忆功能[2]。
NMDA受体是一种离子型麸胺酸盐受体的特别型态。NMDA(N-甲基-D-天门冬胺酸)是一种选择性致效剂,可以与NMDA受体结合,但是无法和其他麸胺酸盐受体结合。NMDA受体的结合,会导致离子通道非选择性地开启,使阳离子通过,进而使平衡电位改变至接近0毫伏特。NMDA受体进行活化,必须依赖电压,这会导致离子通道会阻挡细胞外的Mg2+与Zn2+离子通过,并允许Na+离子与少量Ca2+离子流入细胞,以及使K+离子流出细胞,并保持电压的依赖性[3][4][5][6]。
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参考文献
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- ↑ Li F, Tsien JZ. Memory and the NMDA receptors. N. Engl. J. Med. 2009, 361 (3): 302–3. PMC 3703758 . PMID 19605837. doi:10.1056/NEJMcibr0902052.
- ↑ Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol. Rev. 1999-03, 51 (1): 7–61. PMID 10049997.
- ↑ Liu Y, Zhang J. Recent development in NMDA receptors. Chin. Med. J. 2000-10, 113 (10): 948–56 [2014-04-27]. PMID 11775847.
- ↑ Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 2001-06, 11 (3): 327–35 [2014-04-27]. PMID 11399431. doi:10.1016/S0959-4388(00)00215-4.
- ↑ Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol. 2007-02, 7 (1): 39–47. PMID 17088105. doi:10.1016/j.coph.2006.08.011.