PRNP（朊蛋白）为人类主要朊毒体蛋白PrP的基因编码，也称之为CD230（分化簇230）[1][2][3][4]。该蛋白的主要表达于神经系统，但也会表达在人体其他组织[5][6][7]。
参考文献
- ↑ Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ. Molecular cloning of a human prion protein cDNA. DNA. August 1986, 5 (4): 315–24. PMID 3755672. doi:10.1089/dna.1986.5.315.
- ↑ Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T. Assignment of the human and mouse prion protein genes to homologous chromosomes. Proc. Natl. Acad. Sci. U.S.A. October 1986, 83 (19): 7358–62. Bibcode:1986PNAS...83.7358S. PMC 386716
. PMID 3094007. doi:10.1073/pnas.83.19.7358.
- ↑ Liao YC, Lebo RV, Clawson GA, Smuckler EA. Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications. Science. July 1986, 233 (4761): 364–7. Bibcode:1986Sci...233..364L. PMID 3014653. doi:10.1126/science.3014653.
- ↑ Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochem. Biophys. Res. Commun. October 1986, 140 (2): 758–65. PMID 2877664. doi:10.1016/0006-291X(86)90796-5.
- ↑ Prusiner SB. Shattuck lecture--neurodegenerative diseases and prions. N Engl J Med. 2001, 344 (20): 1516–26. PMID 11357156. doi:10.1056/NEJM200105173442006.
- ↑ Weissmann C. The state of the prion. Nat Rev Microbiol. 2004, 2 (11): 861–71. PMID 15494743. doi:10.1038/nrmicro1025.
- ↑ Zomosa-Signoret V, Arnaud JD, Fontes P, Alvarez-Martinez MT, Liautard JP. Physiological role of the cellular prion protein (PDF). Vet. Res. 2008, 39 (4): 9 [2020-04-07]. PMID 18073096. doi:10.1051/vetres:2007048.