曲唑酮

**曲唑酮**
系统（IUPAC）命名名称
	2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
临床数据
商品名	以多种商品名行销于世界各地
Drugs.com	Monograph
MedlinePlus	a681038
妊娠分级	US: C (不排除有风险的可能) ; ;
给药途径	口服给药（片剂）
合法状态
合法状态	AU: 限医生处方 (S4) ; CA: 处方药（℞-only） ; UK: 处方药（℞-only） (POM) ; US: 处方药（℞-only） ;
药代动力学数据
生物利用度	口服给药: 65%
蛋白结合度	89–95%
代谢	肝脏（CYP3A4）
代谢产物	mCPP
开始出现药效	口服给药：1小时([[:Tmax\|Tmax]])
生物半衰期	Trazodone IR: 7 hours; Trazodone ER: 10 hours; mCPP: 4–8 hours
排泄	尿：70–75%; 粪便：21%
识别信息
CAS注册号	19794-93-5
ATC代码	N06AX05
PubChem	CID 5533
IUPHAR/BPS	213
DrugBank	DB00656
ChemSpider	5332
UNII	YBK48BXK30
KEGG	D08626
ChEBI	CHEBI:9654
ChEMBL	CHEMBL621
其他名称	AF-1161
化学信息
化学式	C19H22ClN5O
摩尔质量	371.8641 g/mol
	SMILES Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4; ;
	InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 ; Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N ;

曲唑酮（英语：Trazodone）是一种口服抗抑郁药^[8]，用来治疗重性抑郁障碍、焦虑症，也配合其他药品来治疗酒精依赖^[8]。Trazodone以多种商品名行销于世界各地^[1]^[9]。

常见的副作用包含口干、头昏、呕吐和头痛^[8]，较为严重的副作用为：自杀、躁狂导致之双极性精神症状、心律不整、阴茎异常勃起^[8]。目前还不清楚在怀孕或哺乳期间使用是否安全^[10]。该药物品属于苯基哌嗪（phenylpiperazine）类药物，为一种血清素拮抗剂和再摄取抑制剂（SARI）^[11]^[12]，Trazodone还具有镇静的副作用^[13]。

该药品于1981年在美国批准用于医疗用途^[8]，现已有通用名药物上市^[8]。截至2019年，每月剂量在英国公医（NHS）的采购药价约7.46英镑^[14]。2018年，美国的每月剂量批发价约4.53美元^[15]。2016年，它是美国第24大处方用药，单年处方超过2500万笔 ^[16]。

文献来源

↑ ^1.0 ^1.1 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013.^{[与来源不符]}
↑ Trazodone. DrugBank. [2015-06-07].
↑ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 （英语）.
↑ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 2012-12-06: 68–. ISBN 978-3-642-18500-7.
↑ MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [2017-04-20].
↑ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9.
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [2018-01-08].
↑ Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [2018-01-08].
↑ Trazodone Use During Pregnancy. Drugs.com. [2018-01-07].
↑ Stahl, Stephen M. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. 2008: 567. ISBN 9780521857024 （英语）.
↑ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2008: 586. ISBN 9780781768795 （英语）.
↑ British national formulary : BNF 69 69. British Medical Association. 2015: 257–258. ISBN 9780857111562.
↑ British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 367. ISBN 9780857113382.
↑ NADAC as of 2018-01-03. Centers for Medicare and Medicaid Services. [2018-01-07] （英语）.
↑ The Top 300 of 2019. clincalc.com. [2018-12-22].

[genericnames-1] 1.0 ^1.1 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016

[DrugPoint-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013.^{[与来源不符]}

[3] Trazodone. DrugBank. [2015-06-07].

[4] Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 （英语）.

[PreskornStanga2012-5] Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 2012-12-06: 68–. ISBN 978-3-642-18500-7.

[6] MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [2017-04-20].

[SchatzbergNemeroff2017-7] Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9.

[AHFS2018-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [2018-01-08].

[自动生成1-9] Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [2018-01-08].

[10] Trazodone Use During Pregnancy. Drugs.com. [2018-01-07].

[11] Stahl, Stephen M. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. 2008: 567. ISBN 9780521857024 （英语）.

[12] Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2008: 586. ISBN 9780781768795 （英语）.

[BNF69-13] British national formulary : BNF 69 69. British Medical Association. 2015: 257–258. ISBN 9780857111562.

[BNF76-14] British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 367. ISBN 9780857113382.

[15] NADAC as of 2018-01-03. Centers for Medicare and Medicaid Services. [2018-01-07] （英语）.

[16] The Top 300 of 2019. clincalc.com. [2018-12-22].

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