 | |
| 系统（IUPAC）命名名称 | |
|---|---|
(RS)-5-(cyclohex-1-en-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione | |
| 药代动力学数据 | |
| 蛋白结合度 | 25% |
| 识别信息 | |
| CAS注册号 | 56-29-1  50-09-9（sodium salt） |
| ATC代码 | N01AF02 N05 |
| PubChem | CID 3608 |
| DrugBank | DB01355 |
| ChemSpider | 3482 |
| UNII | AL8Z8K3P6S |
| KEGG | D01071 |
| ChEBI | CHEBI:5706 |
| ChEMBL | CHEMBL7728 |
| 化学信息 | |
| 化学式 | C12H16N2O3 |
| 摩尔质量 | 236.267 g/mol |
| |
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环己巴比妥(Hexobarbital、hexobarbitone)是一种具有镇静和催眠效果的巴比妥衍生物。在20世纪40至50年代用于外科手术麻醉，因为它起效快、催睡时间短并且代谢迅速。但使用环己巴比妥很难控制麻醉的深度，故有时非常危险。现时采用的麻醉药物更加安全，在巴比妥类药物中，戊硫代巴比妥代替了环己巴比妥。但有时巴比妥仍被用于科学研究中。
延伸阅读
- Reiko Takenoshita, Satoshi Toki. [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan. 2004-12, 124 (12): 857–871 [2019-02-13]. ISSN 0031-6903. PMID 15577260.
- G. Wahlström. A study of the duration of acute tolerance induced with hexobarbital in male rats. Pharmacology, Biochemistry, and Behavior. 1998-4, 59 (4): 945–948 [2019-02-13]. ISSN 0091-3057. PMID 9586853.
- S. Korkmaz, E. Ljungblad, G. Wahlström. Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat. Brain Research. 1995-04-10, 676 (2): 371–377 [2019-02-13]. ISSN 0006-8993. PMID 7614008.
- V. Dall, U. Orntoft, A. Schmidt, L. Nordholm. Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital. Pharmacology, Biochemistry, and Behavior. 1993-9, 46 (1): 73–76 [2019-02-13]. ISSN 0091-3057. PMID 8255925.